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Links between growth hormone and aging. Serum gastrin level in patients with colorectal adenoma or carcinoma. Kasprzak A, Adamek A. Elevated serum gastrin levels in patients with colorectal neoplasia.

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Insulin-like growth factor-1 IGF-1 — structure and the role in the human body. Pediatric Endocrinology Diabetes and Metabolism. APA Filus, A. Pediatric Endocrinology Diabetes and Metabolism, 20 4. Chicago Filus, Alicja, and Zygmunt Zdrojewicz. Pediatric Endocrinology Diabetes and Metabolism 20 4. Harvard Filus, A. MLA Filus, Alicja et al. Vancouver Filus A, Zdrojewicz Z. They belong to the structure of polypeptide hormones homologous to proinsulin. They are characterized by a wide range of activities.

IGF-1 is a key mediator of most tissue effects of growth hormone GH. In addition to effects on growth processes of the body, is also an important factor for cell homeostasis, is subject to both endocrine and tissue-specific auto- and paracrine regulation.

In this paper, the current, general knowledge on the structure, function and mechanism of biological effects of IGF-1 in the human body was presented. Attention was also drawn to the directions of use of IGf-1 in the treatment of other diseases than the diseases of the hypothalamic-pituitary and growth disorders in children.

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